Rejuran Healer vs Rejuran HB Plus: What Is the Difference?

Rejuran Healer and Rejuran HB Plus are both injectable skin boosters from the Rejuran line, but their formulations are different. Rejuran Healer is centered on polynucleotides (PN) for skin regeneration and quality, while HB Plus combines PN with hyaluronic acid and lidocaine for additional hydration and a more comfortable treatment experience. For foreign patients visiting Seoul, the choice often comes down to skin goals, hydration needs, and sensitivity to injection pain.



1. What Is the Difference Between Rejuran Healer and HB Plus?

Both products share polynucleotide (PN) as their main regenerative ingredient, but HB Plus adds two components.

Rejuran Healer

• Primarily contains polynucleotide (PN).
• Focuses on skin regeneration and overall skin quality.
• Commonly used for fine lines, elasticity, texture, and skin resilience.
• Does not specifically add an anesthetic to the formulation.
• May feel more uncomfortable during injection because multiple small injections are typically required.

Rejuran HB Plus

• Contains PN + hyaluronic acid (HA) + lidocaine.
• Provides the regenerative approach associated with PN while adding hydration support.
• Lidocaine is included to reduce injection discomfort.
• Often considered by patients who want Rejuran but are concerned about pain.
• Can provide a more hydrated and dewy skin appearance.

In short, Healer is the more straightforward PN-focused formulation, while HB Plus adds hydration and pain-reduction components.

2. Rejuran Healer vs HB Plus for Different Skin Concerns

The two versions can overlap in their benefits, so the best choice depends on what you want to improve.

Rejuran Healer may be considered for:

• Fine lines
• Reduced elasticity
• Rough or uneven texture
• Thin or stressed-looking skin
• Overall skin regeneration
• Early signs of skin aging
• Improving skin resilience

Because the formulation is centered on PN, Healer is often selected when the priority is overall skin quality and regeneration.

Rejuran HB Plus may be considered for:

• Dry or dehydrated skin
• Fine lines combined with dryness
• Reduced elasticity
• Dull or tired-looking skin
• Patients who want hydration together with skin regeneration
• Patients concerned about the discomfort of traditional Rejuran

The added HA helps support moisture retention, while lidocaine is intended to reduce the discomfort associated with injection.

If your main concern is skin repair and resilience, Healer may be a straightforward choice. If your skin is also noticeably dry and you want a more comfortable procedure, HB Plus may be considered.

3. Which One Is Less Painful?

Pain is one of the biggest practical differences between the two.

Rejuran Healer is commonly administered through multiple small injections into the skin. Because the product itself does not contain lidocaine, patients may experience noticeable stinging or pressure during treatment. Clinics commonly use topical numbing cream beforehand to improve comfort.

HB Plus contains lidocaine within the formulation, which is intended to reduce injection discomfort. The formulation also includes HA, which may make the product easier to inject compared with the original formulation.

However, “less painful” does not mean completely painless.

Your experience can still depend on:

• Individual pain sensitivity
• Injection technique
• Treatment area
• Needle size
• Number of injection points
• Numbing method
• Skin thickness

HB Plus is generally positioned as the more comfortable option, but pain varies between patients.

Patients with a known lidocaine allergy or sensitivity to local anesthetics should inform the medical staff before treatment. The manufacturer's instructions also list hypersensitivity to the product's components, including lidocaine, as a contraindication.

4. Treatment Process, Results and Downtime

The basic treatment process is similar because both are injectable skin boosters.

Rejuran Healer

A typical treatment involves:

1. Consultation and skin assessment
2. Cleansing and preparation
3. Topical numbing
4. Multiple injections into the selected skin area
5. Cooling or soothing care afterward

Small raised bumps, redness, swelling, tenderness, or bruising may occur after treatment. These reactions generally improve over the following days.

Rejuran is designed for gradual improvement rather than immediate facial contour changes. Patients commonly seek improvements in skin texture, elasticity, fine lines, and overall skin condition over a course of treatments.

Rejuran HB Plus

The process is similar:

1. Consultation and skin assessment
2. Cleansing and preparation
3. Numbing if required
4. HB Plus injections
5. Cooling and post-treatment care

Because HB Plus contains HA, small injection bumps or swelling can sometimes remain visible for a little longer than with a PN-only formulation.

Some Korean clinics recommend a series of treatments at intervals of several weeks, but the appropriate number of sessions depends on the patient's skin condition and treatment goals.

For either product, follow the clinic's aftercare instructions and temporarily avoid excessive heat, alcohol, intense exercise, and unnecessary irritation when advised.

5. How Much Does Rejuran Healer and HB Plus Cost in Korea?

Prices vary depending on the amount used, treatment area, injection technique, clinic, and promotional pricing.

As a general 2026 Seoul price guide:

Rejuran Healer

• 1cc: approximately ₩150,000–₩300,000
• 2cc: approximately ₩200,000–₩500,000
• 4cc: approximately ₩400,000–₩800,000+
• Larger treatment plans: approximately ₩800,000–₩1,000,000+

Rejuran HB Plus

• 1cc: approximately ₩200,000–₩350,000
• 2cc: approximately ₩300,000–₩550,000
• 4cc: approximately ₩500,000–₩900,000+
• Larger treatment plans: approximately ₩800,000–₩1,200,000+

HB Plus can be priced somewhat higher because it contains additional HA and lidocaine and is a different formulation. Actual clinic prices can vary considerably.

Foreign patients should confirm:

• Exact Rejuran formulation
• Amount of product used
• Treatment area
• Number of injection points
• Whether numbing is included
• Whether VAT is included
• Whether the quoted price is promotional

Do not compare Healer and HB Plus based only on the headline price. A lower price may represent a smaller amount or a different treatment area.

6. Which Rejuran Should Foreign Patients Choose?

The simplest way to compare the two is to consider your main priority.

Consider Rejuran Healer if you want:

• PN-focused skin regeneration
• Improved skin texture
• Better elasticity
• Fine-line improvement
• Overall skin-quality treatment

Consider Rejuran HB Plus if you want:

• Skin regeneration plus hydration
• A more hydrated, dewy appearance
• Treatment for dry or dehydrated skin
• A more comfortable injection experience
• A skin booster that combines PN, HA, and lidocaine

Neither version is automatically better. The difference is mainly what has been added to the PN base and how that changes the treatment experience and focus.

For foreign patients visiting Seoul, it is especially important to confirm the exact formulation before treatment. Simply asking for “Rejuran” may not be enough because the Rejuran line includes different formulations designed for different purposes.

Frequently Asked Questions

Is Rejuran HB Plus better than Rejuran Healer?
Neither is universally better. Healer is more focused on PN-based skin regeneration, while HB Plus adds hydration and lidocaine for greater comfort.

Why is Rejuran HB Plus less painful?
HB Plus contains lidocaine, a local anesthetic, which is intended to reduce the stinging and discomfort associated with injections.

Does HB Plus provide better hydration than Rejuran Healer?
HB Plus contains hyaluronic acid, so it provides an additional hydration-focused component that is not present in the PN-only Healer formulation.

Which Rejuran is better for dry skin?
HB Plus may be considered when dryness or dehydration is a major concern because it combines PN with HA. Healer may be considered when skin regeneration is the primary goal.

Can I switch between Rejuran Healer and HB Plus?
Treatment plans can be adjusted over time, but the appropriate product and schedule should be determined by a qualified medical professional based on your skin condition and previous treatments.

Can foreigners get Rejuran Healer or HB Plus in Seoul?
Yes. Both formulations are widely offered at Korean aesthetic and dermatology clinics. International patients should confirm the exact product, dosage, price, and aftercare instructions before treatment.

Final Thoughts

Rejuran Healer and HB Plus share the same PN-based foundation but are designed with different priorities. Healer focuses on PN-based skin regeneration, while HB Plus adds hydration and lidocaine for a more comfortable treatment experience.

For foreign patients visiting Korea, the choice should depend on your skin condition, hydration needs, and tolerance for injection discomfort, rather than assuming one formulation is always superior.